Although adverse tamoxifen effects on endometrial cells remain elusive, our work identifies elevated AGR2 as a candidate tamoxifen dependent mechanism of action responsible for increased incidence of endometrial cancer <a href=http://clomid.mom/>metformin and clomid</a> GEO2R, an online analyzing tool of GEO DataSets, was utilized to screen differentially expressed genes in expression microarray GSE54002, GSE65194, and differentially methylated genes in methylation microarray GSE20713, GSE32393, separately